Which of the following requires IACUC approval?

IACUC approval is essential for any modifications to research protocols that could impact animal welfare or the integrity of the research. Changing the drug dosage can significantly affect the animals’ pain levels, health, and overall wellbeing. This type of change may require the review and approval of the IACUC to ensure that it aligns with ethical standards and complies with regulations regarding veterinary care and humane treatment.

In contrast, while increasing the number of animals used, changing the housing environment, and adding a new research team member may also necessitate oversight, they do not directly relate to the specific welfare implications that changing a drug dosage does. These changes might still require modification or review but are often handled differently within institutional protocols. Therefore, the need for IACUC approval focuses particularly on changes that directly influence animal health outcomes, such as adjustments to drug dosages, ensuring that all alterations uphold ethical research practices and minimize harm.