What should be included in animal protocols for justification of species choice?

The justification of species choice in animal protocols is crucial for ensuring that the animal model selected is appropriate for the research question being addressed. A scientific rationale is fundamental in demonstrating that the chosen species is the most relevant for achieving the study's goals. This may include considerations such as physiological, genetic, and anatomical similarities to humans (if the research aims to translate results to human health), or the species' specific characteristics that make them suitable for the particular type of study being conducted.

Incorporating scientific rationale shows that careful thought has been given to the choice of species, emphasizing that the selection is rooted in evidence and logical reasoning, and not arbitrary or based solely on convenience. This approach aligns with ethical standards, as it seeks the best alternatives that minimize suffering while ensuring the validity of the results.

While historical significance can provide context, it does not adequately replace the need for a scientific basis. Widely used species may not always be the best choice for a specific study, as relevance to the research question is critical. References to previous studies can support the justification but should complement the scientific rationale rather than serve as a standalone justification. Thus, a well-rounded protocol will emphasize the scientific rationale as the core of the justification for species selection.